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No extra cancer risk for metal-on-metal hip replacement patients

London, Wed, 04 Apr 2012 ANI
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London, April 4 (ANI): Patients who have had metal-on-metal hip replacements have no more risk of developing cancer in the first seven years after surgery than the general population, a new study has claimed.

But the study stresses that a longer-term study is required for further confirmation.

A recent BMJ and BBC Newsnight investigation looked into the potentially high level of toxic metals from failing hip implants which may, in future, affect thousands of people around the world. The investigation also looked at why these hip replacements were allowed despite the risks being known and documented for decades. T

This study, commissioned by the National Joint Registry of England and Wales and carried out by authors from the Universities of Bristol and Exeter, looks at whether these concerns are valid.

The registry contains records of over one million procedures from at least 97percent of orthopaedic units. Every year registry data and hospital episode statistics are linked up to check how patients who have had joint replacements are faring.

In this study cancer rates in patients with metal-on-metal hip replacements were compared with both a group of patients who had other hip bearing surfaces implanted and the general population.

Overall, 14 percent of registered patients had some type of metal-on-metal bearing surface: 7 percent had a stemmed metal-on-metal prosthesis and 7 percent had a resurfacing procedure.

The researchers compared patients' outcomes using mathematical modelling. The models included the age and sex of the patient as well as three measures of general health at the time of hip surgery (the American Society of Anaesthesiologists grade that scores the patient's other serious illnesses, the number of distinct diagnostic codes recorded at time of surgery, and the number of NHS funded admissions to hospital in the previous five years).

The researchers however said that comparison with the general population is not straightforward as hip replacement patients "tend to be healthier than others of the same gender and age group".

Results show that the chance of a 60 year old man with moderate health and a metal-on-metal stemmed hip replacement being diagnosed with cancer in the five years following surgery is 6.2 percent, compared to 6.7 percent chance with hip replacement using other bearing surfaces.

For women, these figures were 4.0 percent for metal-on-metal stemmed hip replacement and 4.4 percent for other bearing surfaces. Further results show that the incidence of cancer diagnosis is low after hip replacement and lower than that predicted for the age and sex matched general population.

The researchers hope that this study will help clinicians reassure patients that the "risk of cancer for hip replacement patients is relatively low" with no evidence of an increase in cancer associated with metal-on-metal hips.

They added though that this only shows results for up to seven years following surgery and the analysis of long-term data is required over the next few decades as some cancers take many years to develop. (ANI)

The finding has been just published on bmj.com.(ANI)

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