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Mechanism of ancient metabolism evolution discovered

Washington, Fri, 20 Jan 2012 ANI

Washington, Jan 20 (ANI): In a new study, scientists have discovered the mechanism of evolution of the primordial metabolism.


Volcanic-hydrothermal flow channels offer a chemically unique environment, which at first glance appears hostile to life. It is defined by cracks in the crust of the earth, through which water flows, laden with volcanic gases are contacting a diversity of minerals.


Yet, it is precisely this extreme environment, where the two mechanisms could have emerged, which are at the root of all life - the multiplication of biomolecules (reproduction) and the emergence of new biomolecules on the basis of previously formed biomolecules (evolution).


At the outset of this concatenation of reactions that led eventually to the formation of cellular forms of life there are only a few amino acids, which are formed from volcanic gases by mineral catalysis.


Akin to a domino stone that triggers a whole avalanche, these first biomolecules stimulate not only their own further synthesis but also the production of wholly new biomolecules.


"In this manner life begins by necessity in accordance with pre-established laws of chemistry and in a pre-determined direction," Gunter Wachtershauser, honorary professor for evolutionary biochemistry at the University of Regensburg, said.


He developed the mechanism of a self-generating metabolism - theoretically, alas, an experimental demonstration has been lacking so far.


Now, scientists around Claudia Huber and Wolfgang Eisenreich, at the Chair of Biochemistry in the Department of Chemistry at the TUM in close cooperation with Wachtershauser, managed for the first time to demonstrate experimentally the possibility of such a self-stimulating mechanism.


A catalyst consisting of compounds of the transition metals nickel, cobalt or iron has the lead role in these reactions. It provides not only for the formation of the first biomolecules, but it also initiates the concatenation of reactions.


The reason behind this is that the biomolecules just newly formed from the volcanic gases engage the centre of the transition metal catalyst to enable further chemical reactions bringing forth wholly new biomolecules.


"This coupling between the catalyst and an organic reaction product is the first step," Wachtershauser said.


"Life arises, if subsequently a whole cascade of further couplings takes place, and this primordial life leads eventually to the formation of genetic material and of the first cells," he said.


The scientists simulated in their experiments the conditions of volcanic-hydrothermal flow channels and established an aqueous-organometallic system that produces a whole suite of different biomolecules, among them the amino acids glycin and alanin.


Here the carbon source was provided by a cyano compound and the reducing agent by carbon monoxide. Nickel compounds turned out to be the most effective catalysts in these experiments.


They then added the products glycin and alanin to another system, that generated again two new biomolecules.


The researchers found that that two amino acids increased the productivity of the second system by a factor of five.


The results of the scientists show that an origin and evolution of life in hot water of volcanic flow ducts is feasible. The results reveal advantages of the theory compared to other approaches.


Within the flow ducts temperature, pressure and pH change along the flow path, and thereby a graded spectrum of conditions is offered that is appropriate for all stages of early evolution up to the formation of genetic material (RNA/DNA). (ANI)


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