- Breast-fed babies less likely to become angry and irritable adults
- Rheumatoid arthritis drug halts organ damage in inflammatory genetic disorder
- Both maternal and paternal age behind autism
- Loneliness in old age 'worse than smoking'
- Southampton Varsity identify key peptides that could lead to universal vaccine for influenza
- Pregnant women can undergo chemotherapy 'without harming baby'
Study sheds new light on chemotherapy drug-induced hearing damage
Washington, December 31 (ANI): Scientists at a leading European medical university have found out why chemotherapy using cisplatin often lead to hearing problems, but a treatment with oxaliplatin rarely does, despite both drugs being platinum compounds.
A research team led by Dr. Victoria Hellberg, of Karolinska Institutet in Stockholm, measured the amount of cisplatin and oxaliplatin that reached the cochlea in guinea pigs following intravenous dosing of each drug.
The researchers observed that the total platinum concentration in the cochlea was more than five-fold higher with cisplatin than with oxaliplatin following intravenous injection.
They said that the perilymphatic drug concentration was also higher in the cisplatin-treated animals than in those exposed to oxaliplatin.
"The differences in cochlear kinetics and cellular uptake that we found in the hearing end organ are sufficient to explain the difference in ototoxicity (drug-induced hearing damage) between cisplatin and oxaliplatin," the authors conclude.
The study has been reported in the Journal of National Cancer Institute. (ANI)
Lipstick can raise Breast Cancer: Study.
Job flexibility helps out a healthy lifestyle: Study.
Exposure to Tobacco advertising results in increased use: Study.
First two years of child crucial for IQ development: Study.
Study links length of ring finger and arthritis.
|
|
|
|
|
|
Comments: