Intestinal protein linked to ADHD, other neurological disorders

Washington, Sat, 13 Aug 2011 ANI

Washington, August 13 (ANI): A protein long associated with diarrhea and intestinal function may have a role in ADHD (Attention Deficit Hyperactivity Disorder), and other neurological disorders, according to a new study.

 

Mitchell Cohen, M.D., U.S. author of the study and director of Gastroenterology, Hepatology and Nutrition at Cincinnati Children's Hospital Medical Center together with scientists in China discovered that the receptor guanylyl cyclase-C (GC-C) - primarily thought to be based in the intestine - is also expressed in critical areas of the brain.

 

Using a mouse model developed in Dr. Ralph Giannella's laboratory at the University of Cincinnati, in which the GC-C receptor is deleted, or knocked out, the researchers found the mice exhibit hyperactivity and attention deficits. It is the first time that GC-C has been linked to neuropsychiatric disorder, according to the researchers.

 

"We show that the neurons selectively express GC-C and that its activation amplifies the excitatory responses mediated by other receptors on dopamine neurons in the midbrain," said senior author on the study Dr. Minmin Luo. "Working through a protein kinase called PKG, GC-C activity increases brain dopamine levels and thus regulate mouse attention and activity level."

 

"Efforts to develop activators or inhibitors of the GC-C/PKG signaling pathway may lead to novel treatments for other disorders, such schizophrenia, Parkinson's disease and addiction."

 

The study was recently published in the journal Science. (ANI)

 



Read More: R R Hospital | T B Hospital | G.t.b. Hospital | Jalan Hospital Bhiwani | Millitary Hospital | Gandhi Eye Hospital | Eye Hospital | Hospital Road | Jln Hospital Ajmer Nd Tso | L G Hospital | Civil Hospital | Methodist Hospital Tso Nad | Govt. General Hospital | Govt.gen Hospital | Cg Hospital | Govt Stanley Hospital | Neyveli General Hospital | Ma Rajaji Hospital | Catherin Booth Hospital | Sm Hospital

LATEST IMAGES
Models wearing Shree Raj Mahal Jewelers Jewelery Gaurav Gupta and Shraddha Kapoor at Shree Raj Mahal Jewellers India Couture Week 2014 Shree Raj Mahal Jewellers India Couture Week 2014 Where to buy Samsung Galaxy S5? Samsung Galaxy S5
MORE...
Social bookmark this page



Post comments:
Your Name (*) :
Your Email :
Your Phone :
Your Comment (*):
  Reload Image
 
 

Comments: