Protein linked to Alzheimer's disease controls movement in mice

Washington, Sat, 22 Jun 2013 ANI

Washington, June 22 (ANI): Researchers in Berlin and Munich, Germany and Oxford, United Kingdom, have revealed that a protein well known for its role in Alzheimer's disease controls spindle development in muscle and leads to impaired movement in mice when the protein is absent or treated with inhibitors.

The results suggest that drugs under development to target the beta-secretase-1 protein, which may be potential treatments for Alzheimer's disease, might produce unwanted side effects related to defective movement.

Scientists know that the protein beta-secretase-1 or Bace1, a protease enzyme that breaks down proteins into smaller molecules, is involved in Alzheimer's disease.

Bace1 cleaves the amyloid precursor protein and generates the damaging Abeta peptides that accumulate as plaques in the brain leading to disease.

Now scientists have revealed in more detail how Bace1 works.

"Our results show that mice that lack Bace1 proteins or are treated with inhibitors of the enzyme have difficulties in coordination and walking and also show reduced muscle strength," Carmen Birchmeier, one of the authors of the paper, Professor at the Max-Delbruck-Center for Molecular Medicine in Berlin, Germany, and an EMBO Member, said.

"In addition, we were able to show that the combined activities of Bace1 and another protein, neuregulin-1 or Nrg1, are needed to sustain the muscle spindles in mice and to maintain motor coordination," she said.

The research is published in The EMBO Journal. (ANI)



Read More: United Nations Volunteers | United nations | Germany | United Salt Work | June Pargaon | June Mohide | Shirasdevi | Takarwan | Talkhed So | Warola | Waghora | Mategoan | 3 Eme Center | U.g.c.works | L.w.works(guntur) | K.c.works | Spinning Mills Center | June Belgaum | June Belda | Janata Dal (United) information | Alzheimer

LATEST IMAGES
Dr. Farooq Abdullah at New Delhi World Book Fair 2014 Shahnawaz Hussain address at a Hawkers Dharna DPCC President Arvinder Singh Lovely meets LG Najib Jung Gopal Rai address Training program conducted by AAP Delhi CM promises to hike fair in favor of auto-rickshaw drivers
MORE...
Social bookmark this page



Post comments:
Your Name (*) :
Your Email :
Your Phone :
Your Comment (*):
  Reload Image
 
 

Comments: