Blocking protein in brain may halt Alzheimer's process
Washington, April 26 (ANI): Scientists have discovered a potential strategy for developing treatments to stem the disease process in Alzheimer's disease.
It's based on unclogging removal of toxic debris that accumulates in patients' brains, by blocking activity of a little-known regulator protein called CD33.
"Too much CD33 activity appears to promote late-onset Alzheimer's by preventing support cells from clearing out toxic plaques, key risk factors for the disease," explained Rudolph Tanzi, Ph.D., of Massachusetts General Hospital and Harvard University, a grantee of the NIH's National Institute of Mental Health (NIMH) and National Institute on Aging (NIA).
"Future medications that impede CD33 activity in the brain might help prevent or treat the disorder," Tanzi added.
Variation in the CD33 gene turned up as one of four prime suspects in the largest genome-wide dragnet of Alzheimer's-affected families, reported by Tanzi and colleagues in 2008. The gene was known to make a protein that regulates the immune system, but its function in the brain remained elusive. To discover how it might contribute to Alzheimer's, the researchers brought to bear human genetics, biochemistry and human brain tissue, mouse and cell-based experiments.
They found over-expression of CD33 in support cells, called microglia, in postmortem brains from patients who had late-onset Alzheimer's disease, the most common form of the illness. The more CD33 protein on the cell surface of microglia, the more beta-amyloid protein and plaques - damaging debris - had accumulated in their brains.
Moreover, the researchers discovered that brains of people who inherited a version of the CD33 gene that protected them from Alzheimer's conspicuously showed reduced amounts of CD33 on the surface of microglia and less beta-amyloid.
Brain levels of beta-amyloid and plaques were also markedly reduced in mice engineered to under-express or lack CD33. Microglia cells in these animals were more efficient at clearing out the debris, which the researchers traced to levels of CD33 on the cell surface.
Evidence also suggested that CD33 works in league with another Alzheimer's risk gene in microglia to regulate inflammation in the brain.
Tanzi and colleagues reported their findings in the journal Neuron. (ANI)
Read More: Haffkin Institute Po | Osmania General Hospital So | Govt. General Hospital | Science Institute Lsg So | Karnata Health Institute | Indian Institute Of Technology | Central Institute Of Technolog | Neyveli General Hospital | Vellore Institute Of Technolog | Pasteur Institute | Health Institute Po | Birouli Rural Institute | Morarji Desai National Institute of Yoga | Central Institute of Psychiatry, Ranchi | National Institute of Homeopathy | Gandhigram Rural Institute | National Dairy Research Institute | Birbal Sahni Institute of Palaeobotany | Central Institute of Indian Language | National Institute of Virology | Alzheimer
Dutch say unlikely to reach MH17 site in next days
July 31, 2014 at 3:22 AM
Uganda activists launch court bid to overturn anti-gay law
July 31, 2014 at 3:13 AM
Band 'Massive Attack' dedicates Lebanon gig to Gaza kids
July 31, 2014 at 3:06 AM
Colombia dances new salsa popularized by football team
July 31, 2014 at 2:58 AM
Israeli artillery continues to pound Gaza from border
July 31, 2014 at 2:52 AM
Oaxaca celebrates indigenous culture at Guelaguetza festival
July 31, 2014 at 2:36 AM