Hormone level tied to increased risk of diabetes, breast cancer and death
Washington, October 10 (ANI): A study has linked plasma levels of proneurotensin with the development of diabetes, cardiovascular disease, cardiovascular and total mortality, and breast cancer in women.
Neurotensin, an amino acid peptide primarily expressed in the central nervous system and gastrointestinal tract, regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans, according to researchers.
Proneurotensin is a precursor of the hormone neurotensin.
Olle Melander, M.D., Ph.D., of Lund University, Malmo, Sweden and colleagues conducted a study to test if a fasting plasma concentration of proneurotensin is associated with future risk of diabetes mellitus, cardiovascular disease, breast cancer, and death.
Proneurotensin was measured in plasma from 4,632 fasting participants of the population-based Malmo Diet and Cancer Study baseline examination 1991-1994. Various models were used to evaluate the relationship between baseline proneurotensin and first events and death during long-term follow-up until January 2009, with median (midpoint) follow-up ranging from 13.2 to 15.7 years depending on the disease.
Overall, proneurotensin was related to risk of new diabetes, cardiovascular disease, and cardiovascular mortality, with a significant interaction between proneurotensin and sex on risk of cardiovascular disease.
"Exclusively in women, proneurotensin was related to incident diabetes, cardiovascular disease, breast cancer, total mortality, and cardiovascular mortality," the researchers said.
The researchers noted that the elevation of proneurotensin several years before onset of disease indicates that proneurotensin may be a marker of underlying disease susceptibility rather than an expression of subclinical disease.
"As an observational study, our results do not prove any causation between proneurotensin and cardiometabolic disease and breast cancer," they stated.
The researchers added that the relationships between proneurotensin and all end points were significant in women but not in men; however, because there was only significant interaction between sex and proneurotensin for the outcome of incident cardiovascular disease, it remains to be shown whether the association between proneurotensin and adverse outcome is specific for women.
The study appeared in the latest issue of JAMA. (ANI)
Read More: University Grants Commission (UGC) | Guru Nanak Dev University | New University Campus So | University Campus | Kumaon University Nainital | Gorakhpur University | Agra University | Ayurvedic University | Bundelkhand University So | Mds University Ajmer Dtso | Madras University Po | World University Centre | Pondicherry University | Annamalai University | Tamil University | Bharathidasan University | Cbe Mpl.central Busstand | Bharathiyar University | Cancer | Mahavir Cancer Sansthan and Research Centre Patna
Israeli air strikes kill at least 18 in Gaza after truce collapse
August 21, 2014 at 12:39 AM
Donetsk residents flee the city as shelling intensifies
August 20, 2014 at 11:21 PM
Memories of German WWI atrocities haunt Belgium
August 20, 2014 at 11:06 PM
Lebanese church distributes aid for Iraqi refugees
August 20, 2014 at 11:00 PM
Survivors enlisted in Sierra Leone's Ebola battle
August 20, 2014 at 10:49 PM
"SOUTH AUSTRALIAN PREMIER LAUNCHES DREAM TEAM 15 (NNIS EXCLUSIVE) "
August 20, 2014 at 9:53 PM