Red wine compound `may help improve mobility in seniors`
Washington, August 20 (ANI): Resveratrol - the so-called "miracle molecule" found in red wine, might help improve mobility and prevent life-threatening falls among older people, researchers say.
According to the researchers of the study, this report - based on studies of laboratory mice - could lead to the development of natural products designed to help older Americans live safer and more productive lives.
"Our study suggests that a natural compound like resveratrol, which can be obtained either through dietary supplementation or diet itself, could actually decrease some of the motor deficiencies that are seen in our aging population," Jane E. Cavanaugh, leader of the research team from Duquesne University in Pittsburgh, said.
"And that would, therefore, increase an aging person's quality of life and decrease their risk of hospitalization due to slips and falls," she said.
Cavanaugh notes that falls become more common with advancing age and are the leading cause of injury-related death among people older than 65.
In addition, about one in three older Americans have difficulty with balance or walking, according to the American Geriatrics Society.
These mobility problems are particularly common among older people who have Parkinson's disease and other age-related neurological disorders, Cavanagh said.
However, while drugs can help alleviate some of the motor-related problems in Parkinson's disease, Cavanaugh points out that there are no comparable treatments for balance and walking problems in otherwise healthy older adults.
She and her colleagues set out to rectify that, focusing on natural chemical compounds such as resveratrol.
Previous studies have shown that resveratrol - an antioxidant found in red wine and dark-skinned fruits - might help reduce inflammation, lower cholesterol, slash the risk of heart disease and certain cancers and, perhaps, have some anti-aging effects in the body.
Resveratrol is available as a dietary supplement and is abundant in foods such as red grapes, blueberries and nuts.
To determine its effects on balance and mobility, Cavanaugh, Erika N. Allen and colleagues fed young and old laboratory mice a diet containing resveratrol for eight weeks.
They periodically tested the rodents' ability to navigate a steel mesh balance beam, counting the number of times that each mouse took a misstep. Initially, the older mice had more difficulty manoeuvring on the obstacle.
By week four, the older mice made far fewer missteps and were on par with the young mice.
While it is unclear how resveratrol works in the body, Cavanagh's team found some clues.
In laboratory experiments, they exposed neural cells to a neurotransmitter called dopamine, which in large amounts can induce cell death. However, neurons treated with resveratrol before being exposed to dopamine survived.
On closer examination, the researchers found that resveratrol mitigated the damage done by oxygen free radicals, generated by the breakdown of the dopamine, and activated protein signalling pathways that appeared to promote cell survival.
The findings of the study have been recently presented at the 244th National Meeting and Exposition of the American Chemical Society. (ANI)
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