Latest discovery to help in treating Type 2 diabetes
Washington, Feb 8 (ANI): An important step forward has been taken in understanding how insulin secretion is regulated in the body.
This discovery has important implications for drugs currently in development to treat Type 2 diabetes, a disease which is diagnosed every 10 seconds somewhere throughout the world.
A team led by Dr Vincent Poitout of the University of Montreal Hospital Research Centre (CRCHUM) studies the G protein-coupled free fatty acid receptor (FFA1/GPR40), a molecule that plays a key role in stimulating and regulating the production of insulin, a hormone produced by the pancreas to remove excess glucose from the blood, which otherwise would be toxic.
They demonstrated that glucose in the blood stimulates the expression of the receptor, which in turn prompts the body to produce insulin when glucose and fatty acids rise in the circulation, such as occurs after a meal.
Their accomplishment consists in mapping the intricate pathway taken by glucose to stimulate the expression of the receptor and in identifying the various genetic and cellular processes that are activated in this process. This phenomenon contributes to maintaining the right balance between the intake of nutrients and the production of insulin. That balance is precisely what is upset in type 2 diabetes patients, for whom the production of insulin is deficient, and which leads to a variety of chronic conditions.
Although a new generation of antidiabetic drugs which target this receptor to promote insulin tolerance and production is currently being tested, until now little has been known about precisely how the expression of GPR40 is controlled
"Our work has contributed to a better understanding of how these new drugs work. Our ultimate goal is to allow type 2 diabetes patients to lead a healthy life free from the many complications associated with this disease," said Dr Poitout.
The study was published in the Proceedings of the National Academy of Sciences of USA. (ANI)
Read More: Saint Vincent and Grenadines | R R Hospital | T B Hospital | G.t.b. Hospital | Jalan Hospital Bhiwani | Millitary Hospital | Gandhi Eye Hospital | Military Hospital Po | Hospital Road | Jln Hospital Ajmer Nd Tso | L G Hospital | Civil Hospital | Osmania General Hospital So | Airforce Academy | Govt. General Hospital | Govt.gen Hospital | Agricultural Research Centre | Officer's Training Academy | World University Centre | Ma Rajaji Hospital | Late | Mon
While the dead are buried, a war of words erupts over Ukraine
January 27, 2015 at 2:10 AM
Manuel Neuer meets his waxen image in Berlin
January 27, 2015 at 2:10 AM
Thailand beach road becomes bed race track
January 27, 2015 at 1:45 AM
Rynshu - Menswear Show Autumn/Winter 2015/16 in Paris with interview
January 27, 2015 at 1:14 AM
Angelina Jolie uses her starpower for good
January 27, 2015 at 1:05 AM
Schiaparelli - Haute Couture Fashion Show Spring/Summer 2015 in Paris with interviews
January 27, 2015 at 1:04 AM
AnnaFebruary 8, 2012 at 9:31 PM